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In December 1914, the United States Congress passed the Harrison Narcotics Act which called for control of each phase of the preparation and distribution of medicinal opium, morphine, heroin, cocaine, and any new derivative that could be shown to have similar properties. It made illegal the possession of these controlled substances. The restrictions in the Harrison Act were most recently redefined by the Federal Controlled Substances Act of 1970. The Act lists as a Schedule II Controlled Substance opium and its derivatives and all parts of the P. somniferum plant except the seed.

The first period of large scale heroin smuggling into the United States since its prohibition occurred during the years 1967 through 1971. Turkish opium was processed into heroin in France and then smuggled into New York.

In the mid-1970s Mexican brown heroin appeared. It was sold at a lower price than European heroin and became readily available in the West and Midwest. By the mid-1980s the U.S. heroin market was being supplied from three regions: Mexico, Southwest Asia (Pakistan, Afghanistan, Turkey, Lebanon), and Southeast Asia (Burma, Laos, Thailand). Soon thereafter, South American heroin from Columbia appeared.

In 1997, Southeast Asia still accounts for well over half of the world's opium production. It is estimated that the region has the capacity to produce over 200 metric tons of heroin annually. Although much of it is consumed in Asia, thousands of kilograms of Southeast Asian heroin enter the United States each year.

The chemical structure of opiates is very similar to that of naturally produced compounds called endorphins and enkephalins. These compounds are derived from an amino acid pituitary hormone called beta-lipotropin which when released is cleaved to form met-enkephalin, gamma-endorphin, and beta-endorphin. Opiate molecules, due to their similar structure, engage many of the endorphins' nerve-receptor sites in the brain's pleasure centers and bring about similar analgesic effects. In the human body, a pain stimulus usually exites an immediate protective reaction followed by the release of endorphins to relieve discomfort and reward the mental learning process. Opiates mimic high levels of endorphins to produce intense euphoria and a heightened state of well-being. Regular use results in increased tolerance and the need for greater quantities of the drug. Profound physical and psychological dependence results from regular use and rapid cessation brings about withdrawal sickness.

In addition to the pleasure/pain centers, there is also a concentration of opiate receptors in the respiratory center of the brain. Opiates have an inhibiting effect on these cells and in the case of an overdose, respiration can come to a complete halt. Opiates also inhibit sensitivity to the impulse to cough.

A third location for these receptors is in the brain's vomiting center. Opiate use causes nausea and vomiting. Tolerance for this effect is built up very quickly. Opiates effect the digestive system by inhibiting intestinal peristalsis. Long before they were used as painkillers, opiates were used to control diarrhea.

The opium poppy, Papaver somniferum, is an annual plant. From a very small round seed, it grows, flowers, and bears fruit (seed pods) only once. The entire growth cycle for most varieties of this plant takes about 120 days. The seeds of P. somniferum can be distinguished from other species by the appearance of a fine secondary fishnet reticulation within the spaces of the coarse reticulation found all over their surface. When compared with other Papaver species, P. somniferum plants will have their leaves arranged along the stem of the plant, rather than basal leaves, and the leaves and stem will be 'glabrous' (hairless). The tiny seeds germinate quickly, given warmth and sufficient moisture. Sprouts appear in fourteen to twenty-one days. In less than six weeks the young plant has grown four large leaves and resembles a small cabbage in appearance. The lobed, dentate leaves are glaucous green with a dull gray or blue tint.

Within sixty days, the plant will grow from one to two feet in height, with one primary, long, smooth stem. The upper portion of this stem is without leaves and is the 'peduncle'. One or more secondary stems, called 'tillers', may grow from the main stem of the plant. Single poppy plants in Southeast Asia often have one or more tillers.

As the plant grows tall, the main stem and each tiller terminates in a flower bud. During the development of the bud, the peduncle portion of the stem elongates and forms a distinctive 'hook' which causes the bud to be turned upside down. As the flower develops, the peduncle straightens and the buds point upward. A day or two after the buds first point upward, the two outer segments of the bud, called 'sepals,' fall away, exposing the flower petals.

Opium poppies generally flower after about ninety days of growth and continue to flower for two to three weeks. The exposed flower blossom is at first crushed and crinkled, but the petals soon expand and become smooth in the sun. Opium poppy flowers have four petals. The petals may be single or double and may be white, pink, reddish purple, crimson red, or variegated. The petals last for two to four days and then drop to reveal a small, round, green fruit which continues to develop. These fruits or pods (also called 'seedpods', 'capsules,' 'bulbs,' or 'poppy heads') are either oblate, elongated, or globular and mature to about the size of a chicken egg. The oblate-shaped pods are more common in Southeast Asia.

The main stem of a fully-matured P. somniferum plant can range between two to five feet in height. The green leaves are oblong, toothed and lobed and are between four to fifteen inches in diameter at maturity. The mature leaves have no commercial value except for use as animal fodder.

Only the pod portion of the plant can produce opium alkaloids. The skin of the poppy pod encloses the wall of the pod ovary. The ovary wall consists of an outer, middle, and inner layer. The plant's latex (opium) is produced within the ovary wall and drains into the middle layer through a system of vessels and tubes within the pod. The cells of the middle layer secrete more than 95 percent of the opium when the pod is scored and harvested.

Cultivators in Mainland Southeast Asia tap the opium from each pod while it remains on the plant. After the opium is scraped, the pods are cut from the stem and allowed to dry. Once dry, the pods are cut open and the seeds are removed and dried in the sun before storing for the following year's planting. An alternative method of collecting planting seeds is to collect them from intentionally unscored pods, because scoring may diminish the quality of the seeds. Aside from being used as planting seed, the poppy seeds may also be used in cooking and in the manufacture of paints and perfumes. Poppy seed oil is straw-yellow in color, odorless, and has a pleasant, almond-like taste. The opium poppy grows best in temperate, warm climates with low humidity. It requires only a moderate amount of water before and during the early stages of growth. In addition, it is a 'long day' photo-responsive plant. As such, it requires long days and short nights before it will develop flowers. The opium poppy plant can be grown in a variety of soils; clay, sandy loam, sandy, and sandy clay, but it responds best to sandy loam soil. This type of soil has good moisture-retentive and nutrient-retentive properties, is easily cultivated, and has a favorable structure for root development. Clay soil types are hard and difficult to pulverize into a good soil texture. The roots of a young poppy plant cannot readily penetrate clay soils, and growth is inhibited. Sandy soil, by contrast, does not retain sufficient water or nutrients for proper growth of the plant.

Excessive moisture or extremely arid conditions will adversely affect the poppy plant's growth and reduce the alkaloid content. Poppy plants can become waterlogged and die after a heavy rainfall in poorly drained soil. Heavy rainfall in the second and third months of growth can leach alkaloids from the plant and spoil the opium harvest. Dull, rainy, or cloudy weather during this critical growth period may reduce both the quantity and the quality of the alkaloid content.

Opium poppies were widely grown as an ornamental plant and for seeds in the United States until the possession of this plant was declared illegal in the Opium Poppy Control Act of 1942. New generations of plants from the self-sown seed of these original poppies can still be seen in many old ornamental gardens.

The major legal opium poppy growing areas in the world today are in govemment-regulated opium farms in lndia, Turkey and Tasmania, Australia. The major illegal growing areas are in the highlands of Mainland Southeast Asia, specifically Burma (Myanmar), Laos, and Thailand, as well as the adjacent areas of southern China and northwestern Vietnam. The area is known as the 'Golden Triangle'. In Southwest Asia, opium poppies are grown in Pakistan, Iran, and Afghanistan. Opium poppy is also grown in Lebanon, Guatemala, Colombia and Mexico.

The highlands of Mainland Southeast Asia, at elevations of 800 meters or more above sea level, are prime poppy growing areas. Generally speaking, these poppy-farming areas do not require irrigation, fertilizer, or insecticides for successful opium yields.

Most of the opium poppies of Southeast Asia are grown in Burma (Myamnar), specifically in the Wa and Kokang areas which are in the northeastern quadrant of the Shan State of Burma. Laos is the second-largest illicit opium-producing country in Southeast Asia and third-largest in the world. While most heroin could be said to be "Made in Myanmar" Afghanistan contributes a large portion of the world's supply - See chart below.

In Laos, poppy is cultivated extensively in Houaphan and Xiangkhoang Provinces, as well as the six other northern provinces: Bokeo, Louangnamtha, Louangphabang, Oudomxai, Phongsali and Xaignabouli. Poppy is also grown in many of the remote, mountainous areas of northern Thailand, particularly in Chiang Mai, Chiang Rai, Mae Hong Son, Nan and Tak Provinces.

In China, opium poppies are cultivated by ethnic minority groups in the mountainous frontier regions of Yunnan Province, particularly along the border area with Burma's Kachin and Shan States. Son La Province, situated between China and Laos, is a major opium poppy cultivation area in Vietnam, as are Lai Chau and Nghe An Provinces.

It is noteworthy that the dominant ethnic groups of Mainland Southeast Asia are not poppy cultivators. The Burmans and Shan of Burma, the Lao of Laos, the Thai of Thailand, the Han Chinese of Yunnan, China, and the Vietnamese of Vietnam are lowlanders and do not traditionally cultivate opium poppies. Rather, it is the ethnic minority highlander groups, such as the Wa, Pa-0, Palaung, Lahu, Lisu, Hmong, and Akha who grow poppies in the highlands of the countries of Southeast Asia.

A typical nuclear family of Mainland Southeast Asian highlanders ranges between five and ten persons, including two to five adults. An average household of poppy farmers can cultivate and harvest about one acre of opium poppy per year. Most of the better fields can support opium poppy cultivation for ten years or more without fertilization, irrigation, or insecticides, before the soil is depleted and new fields must be cleared. In choosing a field to grow opium poppy, soil quality and acidity are critical factors and experienced poppy farmers choose their fields carefully. In Southeast Asia, westerly orientations are typically preferred to optimize sun exposure. Most fields are on mountain slopes at elevations of 1,000 meters (3,000 feet) or more above sea level. Slope gradients of 20 degrees to 40 degrees are considered best for drainage of rain water.

In Mainland Southeast Asia, virgin land is prepared by cutting and piling all brush, vines and small trees in the field during March, at the end of the dry season. After allowing the brush to dry in the hot sun for several days, the field is set afire. This method, called 'slash-and burn' or 'swidden' agriculture, is commonly practiced by dry field farmers - both highland and lowland - throughout Mainland Southeast Asia in order to ready the land for a variety of field crops. The slash-and-burn method is also used to clear fields for poppy cultivation. Before the rainy season in April, fields by the hundreds of thousands all over the region are set ablaze. A fog-like yellow haze hangs over the area for weeks, reducing visibility for hundreds of miles. In the mountains, the dense haze blocks out the sun and stings the eyes.

A typical highlander family will plant an area of two or three rai in opium poppy (2.53 rai is equivalent to one acre). In August or September, toward the end of the rainy season, highland farmers in Southeast Asia prepare fields selected for opium poppy planting. By this time, the ash resulting from the burn-off of the previous dry season has settled into the soil, providing additional nutrients, especially potash. The soil is turned with long-handled hoes after it is softened by the rains. The farmers then break up the large clumps of soil. Weeds and stones are tossed aside and the ground is leveled off.

Traditionally, most highland and upland farmers in Southeast Asia do not use fertilizer for any of their crops, including the opium poppy, but in recent years opium poppy farmers have started using both natural and chemical fertilizers to increase opium poppy yields. Chicken manure, human feces or the regions' abundant bat droppings are often mixed into the planting soil before the opium poppy seed is planted.

Source: Opium - Poppy Cultivation, Morphine and Heroin Manufacture